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overview Aron S. Buchman, MD, is a professor in the Department of Neurological Sciences at Rush University Medical Center in Chicago. Buchman received the degree of bachelor of science, cum laude, from Loyola University of Chicago in 1977. He was a Patinkin Fellow and spent 1979-80 studying medical ethics in Israel at the Regensberg Institute. He earned his doctorate in medicine from Chicago Medical School/University of Health Sciences in 1982. Following an internship in internal medicine at Brookdale Hospital in New York, Buchman returned to Rush for residency training in neurology and a fellowship in movement disorders and clinical neuropharmacology, which he completed in 1987. Buchman received additional fellowship training in clinical electrophysiology and neuromuscular diseases at the University of British Columbia and Vancouver General Hospital in 1987-88. Buchman received board certification in neurology in 1988 and from the American Board of Electrodiagnostic Medicine in 1989. He received added certification in clinical neurophysiology in 1994. Buchman served as director of the EMG Laboratory at Rush from 1988 to 1996 and acting director of the Section on Neuromuscular Diseases in 1997. He received a career development award from the NINDS/NIH from 1994-99 for his work that investigated motor control and motor unit recruitment. Buchman was a research fellow at the NeuroMuscular Research Center at Boston University from 1992-95. He was a visiting scientist in the Department of Applied Mathematics at the Weizmann Institute of Science from 1995-97. Buchman’s research interests include the effects of aging on the motor system. More recently his research has focused on identifying the structural basis of clinical frailty in older persons, exploring the pathologic indices linking risk factors to the development of frailty so as to provide a conceptual basis for the development and testing of interventions to reduce the burden of this common syndrome in older adults. My Scopus ID is 7101625478. My NIH COMMONS name is ABUCHMAN.
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Concept Smoking
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Academic Article Cerebrovascular disease pathology and parkinsonian signs in old age.
Academic Article GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy.
Academic Article Effect of a purpose in life on risk of incident Alzheimer disease and mild cognitive impairment in community-dwelling older persons.
Academic Article Brain pathology contributes to simultaneous change in physical frailty and cognition in old age.
Academic Article Cognitive function is associated with risk aversion in community-based older persons.
Academic Article Emotional neglect in childhood and cerebral infarction in older age.
Academic Article Quantification of the fragmentation of rest-activity patterns in elderly individuals using a state transition analysis.
Academic Article Harm avoidance is associated with progression of parkinsonism in community-dwelling older adults: a prospective cohort study.
Academic Article Combinations of motor measures more strongly predict adverse health outcomes in old age: the rush memory and aging project, a community-based cohort study.
Academic Article Increased fragmentation of rest-activity patterns is associated with a characteristic pattern of cognitive impairment in older individuals.
Academic Article Change in motor function and risk of mortality in older persons.
Academic Article Cognitive function is associated with the development of mobility impairments in community-dwelling elders.
Academic Article Hemoglobin level in older persons and incident Alzheimer disease: prospective cohort analysis.
Academic Article Sleep is related to neuron numbers in the ventrolateral preoptic/intermediate nucleus in older adults with and without Alzheimer's disease.
Academic Article Antihypertensive and Statin Medication Use and Motor Function in Community-Dwelling Older Adults.
Academic Article High CRP with "normal" cognition: a resilient phenotype in old age.
Academic Article Sex difference in daily rhythms of clock gene expression in the aged human cerebral cortex.
Academic Article Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People.
Academic Article The APOE epsilon4 allele is associated with incident mild cognitive impairment among community-dwelling older persons.
Academic Article Effect of purpose in life on the relation between Alzheimer disease pathologic changes on cognitive function in advanced age.
Academic Article A common polymorphism near PER1 and the timing of human behavioral rhythms.
Academic Article Purpose in life is associated with mortality among community-dwelling older persons.
Academic Article Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer's disease.
Academic Article Mixed pathology is more likely in black than white decedents with Alzheimer dementia.
Academic Article Regional Neocortical Gray Matter Structure and Sleep Fragmentation in Older Adults.
Academic Article Association of brain pathology with the progression of frailty in older adults.
Academic Article Purpose in life is associated with a reduced risk of incident disability among community-dwelling older persons.
Academic Article Motoric cognitive risk syndrome: multicountry prevalence and dementia risk.
Academic Article Lewy bodies and olfactory dysfunction in old age.
Academic Article Cognitive frailty.
Academic Article 24-hour rhythms of DNA methylation and their relation with rhythms of RNA expression in the human dorsolateral prefrontal cortex.
Academic Article Motoric cognitive risk syndrome: Multicenter incidence study.
Academic Article Frailty is associated with incident Alzheimer's disease and cognitive decline in the elderly.
Academic Article Negative social interactions and risk of mild cognitive impairment in old age.
Academic Article Pulmonary function, muscle strength, and incident mobility disability in elders.
Academic Article Association of Parkinson disease risk loci with mild parkinsonian signs in older persons.
Academic Article Relation of genomic variants for Alzheimer disease dementia to common neuropathologies.
Academic Article The Rush Memory and Aging Project: study design and baseline characteristics of the study cohort.
Academic Article Terminal decline in motor function.
Academic Article Grip strength and the risk of incident Alzheimer's disease.
Academic Article Association of muscle strength with the risk of Alzheimer disease and the rate of cognitive decline in community-dwelling older persons.
Academic Article At the interface of sensory and motor dysfunctions and Alzheimer's disease.
Academic Article Total daily activity measured with actigraphy and motor function in community-dwelling older persons with and without dementia.
Academic Article Harm avoidance and disability in old age.
Academic Article Loss of motor function in preclinical Alzheimer's disease.
Academic Article Regional brain cortical thinning and systemic inflammation in older persons without dementia.
Academic Article Association between life space and risk of mortality in advanced age.
Academic Article Suprachiasmatic neuron numbers and rest-activity circadian rhythms in older humans.
Academic Article Association of cognition with temporal discounting in community based older persons.
Academic Article Cognitive decline impairs financial and health literacy among community-based older persons without dementia.
Academic Article Gender differences in upper extremity motor performance of older persons.
Academic Article GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology.
Academic Article Using a body-fixed sensor to identify subclinical gait difficulties in older adults with IADL disability: maximizing the output of the timed up and go.
Academic Article Response to Letter Regarding Article, "Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People".
Academic Article Neuroticism, extraversion, and motor function in community-dwelling older persons.
Academic Article Parkinsonism in Older Adults and Its Association With Adverse Health Outcomes and Neuropathology.
Academic Article Olfactory impairment in presymptomatic Alzheimer's disease.
Academic Article Correlates of life space in a volunteer cohort of older adults.
Academic Article CR1 is associated with amyloid plaque burden and age-related cognitive decline.
Academic Article Locus coeruleus neuron density and parkinsonism in older adults without Parkinson's disease.
Academic Article Higher brain BDNF gene expression is associated with slower cognitive decline in older adults.
Academic Article a-Synuclein pathology accumulates in sacral spinal visceral sensory pathways.
Academic Article Association of total daily physical activity with disability in community-dwelling older persons: a prospective cohort study.
Academic Article Physical activity is associated with incident disability in community-based older persons.
Academic Article Vibratory thresholds and mobility in older persons.
Academic Article APOE e4 increases risk for dementia in pure synucleinopathies.
Academic Article Relation of late-life social activity with incident disability among community-dwelling older adults.
Academic Article Temporal course and pathologic basis of unawareness of memory loss in dementia.
Academic Article Odor identification and progression of parkinsonian signs in older persons.
Academic Article Life space and risk of Alzheimer disease, mild cognitive impairment, and cognitive decline in old age.
Academic Article Poor decision making is associated with an increased risk of mortality among community-dwelling older persons without dementia.
Academic Article Physical activity and leg strength predict decline in mobility performance in older persons.
Academic Article Physical frailty is associated with incident mild cognitive impairment in community-based older persons.
Academic Article A genome-wide association study of aging.
Academic Article New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.
Academic Article Total daily activity declines more rapidly with increasing age in older adults.
Academic Article Common variants in DRD2 are associated with sleep duration: the CARe consortium.
Academic Article Transition Between the Timed up and Go Turn to Sit Subtasks: Is Timing Everything?
Academic Article Antiphospholipid antibodies, brain infarcts, and cognitive and motor decline in aging (ABICMA): design of a community-based, longitudinal, clinical-pathological study.
Academic Article Nigral pathology and parkinsonian signs in elders without Parkinson disease.
Academic Article Total daily physical activity and longevity in old age.
Academic Article Body mass index in older persons is associated with Alzheimer disease pathology.
Academic Article The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
Academic Article Musculoskeletal pain is associated with incident mobility disability in community-dwelling elders.
Academic Article Loneliness and the rate of motor decline in old age: the Rush Memory and Aging Project, a community-based cohort study.
Academic Article Visuoperceptual repetition priming and progression of parkinsonian signs in aging.
Academic Article Modification of the relationship of the apolipoprotein E e4 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleep.
Academic Article APOE and cerebral amyloid angiopathy in community-dwelling older persons.
Academic Article Relation of neuropathology to cognition in persons without cognitive impairment.
Academic Article The Role of MAPT Haplotype H2 and Isoform 1N/4R in Parkinsonism of Older Adults.
Academic Article Association between performance on Timed Up and Go subtasks and mild cognitive impairment: further insights into the links between cognitive and motor function.
Academic Article Musculoskeletal pain and incident disability in community-dwelling older adults.
Academic Article Irregular 24-hour activity rhythms and the metabolic syndrome in older adults.
Academic Article Total daily activity is associated with cognition in older persons.
Academic Article Association between late-life social activity and motor decline in older adults.
Academic Article Motor Function Is Associated With Incident Disability in Older African Americans.
Academic Article Physical frailty in older persons is associated with Alzheimer disease pathology.
Academic Article Sleep complaints and incident disability in a community-based cohort study of older persons.
Academic Article Neural reserve, neuronal density in the locus ceruleus, and cognitive decline.
Academic Article Change in motor function and adverse health outcomes in older African-Americans.
Academic Article Brainstem aminergic nuclei and late-life depressive symptoms.
Academic Article Apolipoprotein E e4 allele is associated with more rapid motor decline in older persons.
Academic Article Physical activity, motor function, and white matter hyperintensity burden in healthy older adults.
Academic Article Control of movement distance in Parkinson's disease.
Academic Article Imaging of spinal metastases.
Academic Article Stiff-person syndrome following West Nile fever.
Academic Article Change in frailty and risk of death in older persons.
Academic Article Lower extremity motor function and disability in mild cognitive impairment.
Academic Article Total daily physical activity and the risk of AD and cognitive decline in older adults.
Academic Article What links gait speed and MCI with dementia? A fresh look at the association between motor and cognitive function.
Academic Article Medial plantar nerve testing facilitates identification of polyneuropathy.
Academic Article Botulinum toxin injections for children with excessive drooling.
Academic Article Botulinum toxin injection for spasmodic torticollis: increased magnitude of benefit with electromyographic assistance.
Academic Article Respiratory muscle strength predicts decline in mobility in older persons.
Academic Article Pulmonary function, muscle strength and mortality in old age.
Academic Article Eosinophilia, myositis, and myasthenia gravis associated with a thymoma.
Academic Article Renal function of children receiving long-term parenteral nutrition.
Academic Article Physical activity and motor decline in older persons.
Academic Article The effect of changes in head posture on the patterns of muscle activity in cervical dystonia (CD).
Academic Article GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium.
Academic Article Determining neuromuscular jitter using a monopolar electrode.
Academic Article Risk factors for progression in Parkinson's disease.
Academic Article Incident parkinsonism in older adults without Parkinson disease.
Academic Article Change in body mass index and risk of incident Alzheimer disease.
Academic Article Intrafamilial heterogeneity in hereditary motor neuron disease.
Academic Article Quantitative electromyographic analysis of changes in muscle activity following botulinum toxin therapy for cervical dystonia.
Academic Article Kidney function is associated with the rate of cognitive decline in the elderly.
Academic Article Recovery following the "locked-in" syndrome.
Academic Article Effect of age and gender in the control of elbow flexion movements.
Academic Article Genetic susceptibility for ischemic infarction and arteriolosclerosis based on neuropathologic evaluations.
Academic Article Sleep Fragmentation and the Risk of Incident Alzheimer's Disease and Cognitive Decline in Older Persons.
Academic Article The Relationship of Cerebral Vessel Pathology to Brain Microinfarcts.
Academic Article Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
Academic Article Ex vivo MRI transverse relaxation in community based older persons with and without Alzheimer's dementia.
Academic Article Self-Reported Sleep in Older African Americans and White Americans.
Academic Article Urinary Incontinence, Incident Parkinsonism, and Parkinson's Disease Pathology in Older Adults.
Academic Article The complex genetics of gait speed: genome-wide meta-analysis approach.
Academic Article Author response: Incident parkinsonism in older adults without Parkinson disease.
Academic Article Author response: Incident parkinsonism in older adults without Parkinson disease.
Academic Article Correction: The complex genetics of gait speed: genome-wide meta-analysis approach.
Academic Article A translational approach to capture gait signatures of neurological disorders in mice and humans.
Academic Article A novel approach for assigning levels to monkey and human lumbosacral spinal cord based on ventral horn morphology.
Academic Article Alzheimer's brains show inter-related changes in RNA and lipid metabolism.
Academic Article Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
Academic Article Spinal Arteriolosclerosis Is Common in Older Adults and Associated With Parkinsonism.
Academic Article Spinal Lewy body pathology in older adults without an antemortem diagnosis of Parkinson's disease.
Academic Article Association Between Quantitative Gait and Balance Measures and Total Daily Physical Activity in Community-Dwelling Older Adults.
Academic Article Sleep fragmentation and Parkinson's disease pathology in older adults without Parkinson's disease.
Academic Article Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline.
Academic Article Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
Academic Article Expanding the Toolkit for Studies of Aging.
Academic Article Drosophila p53 is a structural and functional homolog of the tumor suppressor p53.
Academic Article Do subjects with minimal motor features have prodromal Parkinson disease?
Academic Article Defective preprogramming does not account for the clinical deficits of Parkinsons Disease
Academic Article Sarcopenia: A common but under-recognized neurodegenerative condition of aging
Academic Article Participation in late-life social activity is related to motor decline in the elderly
Academic Article Fractal regulation and incident Alzheimer's disease in elderly individuals.
Academic Article Religious Orders Study and Rush Memory and Aging Project.
Academic Article Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia.
Academic Article Watershed microinfarct pathology and cognition in older persons.
Academic Article Seasonal plasticity of cognition and related biological measures in adults with and without Alzheimer disease: Analysis of multiple cohorts.
Academic Article Dietary Patterns and Self-reported Incident Disability in Older Adults.
Academic Article The transition between turning and sitting in patients with Parkinson's disease: A wearable device detects an unexpected sequence of events.
Academic Article Spinal motor neurons and motor function in older adults.
Academic Article Physical activity, common brain pathologies, and cognition in community-dwelling older adults.
Academic Article Disentangling the genetics of lean mass.
Academic Article MIND Diet Associated with Reduced Incidence and Delayed Progression of ParkinsonismA in Old Age.
Academic Article Hippocampal gene expression patterns linked to late-life physical activity oppose age and AD-related transcriptional decline.
Academic Article Incident Mobility Disability, Mild Cognitive Impairment, and Mortality in Community-Dwelling Older Adults.
Academic Article Progressive parkinsonism in older adults is related to the burden of mixed brain pathologies.
Academic Article Total Daily Physical Activity and the Risk of Parkinsonism in Community-Dwelling Older Adults.
Academic Article Expanding instrumented gait testing in the community setting: A portable, depth-sensing camera captures joint motion in older adults.
Academic Article Antiphospholipid Antibodies: Cognitive and Motor Decline, Neuroimaging and Neuropathology.
Award or Honor Receipt National Institute of Health/NINDS Clinical Investigator Development Award (CIDA)
Academic Article Different Combinations of Mobility Metrics Derived From a Wearable Sensor Are Associated With Distinct Health Outcomes in Older Adults.
Academic Article Quantitative mobility metrics from a wearable sensor predict incident parkinsonism in older adults.
Academic Article Neocortical Lewy bodies are associated with impaired odor identification in community-dwelling elders without clinical PD.
Academic Article Genetic risk for Alzheimer's dementia predicts motor deficits through multi-omic systems in older adults.
Academic Article More random motor activity fluctuations predict incident frailty, disability, and mortality.
Academic Article What happens before the first step? A New Approach to Quantifying Gait Initiation Using a Wearable Sensor.
Academic Article Sleep fragmentation, microglial aging, and cognitive impairment in adults with and without Alzheimer's dementia.
Academic Article Total daily physical activity, brain pathologies, and parkinsonism in older adults.
Academic Article Human Brain and Serum Advanced Glycation End Products are Highly Correlated: Preliminary Results of Their Role in Alzheimer Disease and Type 2 Diabetes.
Academic Article Associations Between Cardiovascular Risk, Structural Brain Changes, and Cognitive Decline.
Academic Article Dietary antioxidants associated with slower progression of parkinsonian signs in older adults.
Academic Article Fragmentation of Rest/Activity Patterns in Community-Based Elderly Individuals Predicts Incident Heart Failure.
Academic Article Person-Specific Contributions of Brain Pathologies to Progressive Parkinsonism in Older Adults.
Academic Article Brain pathologies are associated with both the rate and variability of declining motor function in older adults.
Academic Article Association of Cardiovascular Risk Burden With Risk and Progression of Disability: Mediating Role of Cardiovascular Disease and Cognitive Decline.
Academic Article Representation of Older Latinxs in Cohort Studies at the Rush Alzheimer's Disease Center.
Academic Article Automatic Quantification of Tandem Walking Using a Wearable Device: New Insights Into Dynamic Balance and Mobility in Older Adults.
Academic Article Semiautomatic morphometric analysis of skeletal muscle obtained by needle biopsy in older adults.
Academic Article Bayesian Genome-wide TWAS Method to Leverage both cis- and trans-eQTL Information through Summary Statistics.
Academic Article Neuropathologic burden and the degree of frailty in relation to global cognition and dementia.
Academic Article Association of Heel Bone Mineral Density With Incident Disability and Mortality in Community-Dwelling Older Adults.
Academic Article Association of Low Systolic Blood Pressure with Postmortem Amyloid-? and Tau.
Academic Article Deterioration in Motor Function Over Time in Older Adults With Type 2 Diabetes is Associated with Accelerated Cognitive Decline.
Academic Article Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women.
Academic Article Motor function is the primary driver of the associations of sarcopenia and physical frailty with adverse health outcomes in community-dwelling older adults.
Academic Article Incident mobility disability, parkinsonism, and mortality in community-dwelling older adults.
Academic Article Quantitative mobility measures complement the MDS-UPDRS for characterization of Parkinson's disease heterogeneity.
Academic Article Frequency of Parkinsonism and Parkinson Disease in African Americans in the Chicago Community.
Academic Article Systemic brain derived neurotrophic factor but not intestinal barrier integrity is associated with cognitive decline and incident Alzheimer's disease.
Academic Article Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer's dementia.
Academic Article Late-Life Vascular Risk Score in Association With Postmortem Cerebrovascular Disease Brain Pathologies.
Academic Article Disrupted Rest-Activity Rhythms and Cerebral Small Vessel Disease Pathology in Older Adults.
Academic Article Sarcopenia is associated with incident Alzheimer's dementia, mild cognitive impairment, and cognitive decline.
Academic Article Cortical proteins may provide motor resilience in older adults.
Academic Article Objective Assessment of Daytime Napping and Incident Heart Failure in 1140 Community-Dwelling Older Adults: A Prospective, Observational Cohort Study.
Academic Article Association of Lewy Bodies With Age-Related Clinical Characteristics in Black and White Decedents.
Academic Article Circadian disturbances in Alzheimer's disease progression: a prospective observational cohort study of community-based older adults.
Academic Article Physical activity, brain tissue microstructure, and cognition in older adults.
Academic Article Association of cardiovascular risk burden with risk of dementia and brain pathologies: A population-based cohort study.
Academic Article Latent Cognitive Class at Enrollment Predicts Future Cognitive Trajectories of Decline in a Community Sample of Older Adults.
Academic Article Racial Differences in the Effect of HIV Status on Motor and Pulmonary Function and Mobility Disability in Older Adults.
Academic Article Brain ?-Amyloid Links the Association of Change in Body Mass Index With Cognitive Decline in Community-Dwelling Older Adults.
Academic Article Association of White Matter Hyperintensities With Pathology and Progression of Parkinsonism in Aging.
Academic Article Microglial Correlates of Late Life Physical Activity: Relationship with Synaptic and Cognitive Aging in Older Adults.
Academic Article Late-life physical activity relates to brain tissue synaptic integrity markers in older adults.
Academic Article Association of Statins With Cerebral Atherosclerosis and Incident Parkinsonism in Older Adults.
Academic Article Daytime napping and Alzheimer's dementia: A potential bidirectional relationship.
Academic Article Proteome-Wide Discovery of Cortical Proteins That May Provide Motor Resilience to Offset the Negative Effects of Pathologies in Older Adults.
Academic Article Neurodegenerative and Cerebrovascular Brain Pathologies Are Differentially Associated With Declining Grip Strength and Gait In Older Adults.
Academic Article Optimized Glycopeptide Enrichment Method-It Is All About the Sauce.
Academic Article Gait Detection from a Wrist-Worn Sensor Using Machine Learning Methods: A Daily Living Study in Older Adults and People with Parkinson's Disease.
Academic Article Author Response: Association of Statins With Cerebral Atherosclerosis and Incident Parkinsonism in Older Adults.
Academic Article Circadian disturbances and frailty risk in older adults: a prospective cohort study.
Academic Article Brain and spinal cord arteriolosclerosis and its associations with cerebrovascular disease risk factors in community-dwelling older adults.
Academic Article SR-TWAS: Leveraging Multiple Reference Panels to Improve TWAS Power by Ensemble Machine Learning.
Academic Article Effects of Cerebrovascular and Lewy Body Pathology on Parkinsonian Signs in Community-Dwelling Older Adults.
Academic Article A prospective study of the association of cognitive and motor function with odds of life space constriction in older adults.
Academic Article Dual cognitive and mobility impairments and future dementia - Setting a research agenda.
Academic Article A scalable Bayesian functional GWAS method accounting for multivariate quantitative functional annotations with applications for studying Alzheimer disease.
Academic Article Fragmentation of rest periods, astrocyte activation, and cognitive decline in older adults with and without Alzheimer's disease.
Academic Article Correlates of Person-Specific Rates of Change in Sensor-Derived Physical Activity Metrics of Daily Living in the Rush Memory and Aging Project.
Academic Article Dividing attention during the Timed Up and Go enhances associations of several subtask performances with MCI and cognition.
Academic Article Influence of cardiovascular risk burden on pulmonary function trajectory: role of physical and social activities.
Academic Article Association of AK4 Protein From Stem Cell-Derived Neurons With Cognitive Reserve: An Autopsy Study.
Academic Article Risk Models Based on Non-Cognitive Measures May Identify Presymptomatic Alzheimer's Disease.
Academic Article Differential gene expression analysis based on linear mixed model corrects false positive inflation for studying quantitative traits.
Concept Walking Speed
Concept Mental Status and Dementia Tests
Concept Dietary Approaches To Stop Hypertension
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